基于流式细胞的细胞质免疫球蛋白指数与12

Theflowcytometry-definedlightchaincytoplasmicimmunoglobulinindexandanassociated12-geneexpressionsignatureareindependentprognosticfactorsinmultiplemyeloma

摘要原文AspartofTotalTherapy(TT)3b,baselinemarrowaspiratesweresubjectedtotwo-colorflowcytometryofnuclearDNAcontentandcytoplasmicimmunoglobulin(DNA/CIG)aswellasplasmacellgeneexpressionprofiling(GEP).DNA/CIG-derivedparameters,GEPandstandardclinicalvariableswereexaminedfortheireffectsonoverallsurvival(OS)andprogression-freesurvival(PFS).AmongDNA/CIGparameters,thepercentageofthelightchain-restricted(LCR)cellsandtheircytoplasmicimmunoglobulinindex(CIg)werelinkedtopoorout







































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